Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 10/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559250 | 0.90 | KCNE1 (0.44) | KCNE1KCNQ1KCNH2DPP4DPP7 | |
| SCHEMBL6559549 | 0.89 | KCNE1 (0.36) | KCNE1KCNQ1KCNH2DPP4DPP7 | |
| SCHEMBL6560826 | 0.87 | HTR2B (0.35) | KCNE1KCNQ1KCNH2HTR1ASLC6A2 | |
| SCHEMBL6558719 | 0.87 | KCNE1 (0.46) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL7826231 | 0.87 | KCNE1 (0.36) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL7826743 | 0.86 | KCNE1 (0.36) | KCNE1KCNQ1KCNH2HTR1AHTR2C | |
| SCHEMBL4620609 | 0.85 | PSEN1 (0.33) | KCNE1KCNQ1KCNH2PSEN1PSEN2 | |
| SCHEMBL7830067 | 0.84 | KCNE1 (0.37) | KCNE1KCNQ1KCNH2MEN1KMT2A | |
| SCHEMBL6559280 | 0.84 | KCNE1 (0.33) | KCNE1KCNQ1HTR1ASLC6A2HTR2C | |
| SCHEMBL7471976 | 0.83 | KCNE1 (0.33) | KCNE1KCNQ1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |