Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 3/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559324 | 0.89 | KCNE1 (0.46) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL7468526 | 0.86 | KCNE1 (0.49) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL7474635 | 0.85 | KCNE1 (0.48) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL7472489 | 0.85 | KCNE1 (0.48) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL6559266 | 0.84 | KCNE1 (0.52) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL8479232 | 0.81 | KCNE1 (0.47) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL6558722 | 0.80 | KCNE1 (0.48) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL7473039 | 0.80 | KCNE1 (0.47) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL7479633 | 0.80 | KCNE1 (0.43) | KCNE1KCNQ1TRPV1CYP3A4AKR1B1 | |
| SCHEMBL7474755 | 0.80 | KCNE1 (0.43) | KCNE1KCNQ1TRPV1CTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |