Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 5/20 | 0.37 |
| ▸ | BACE1 | P56817 | 5/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559316 | 0.96 | TRPV1 (0.38) | TRPV1KCNA5CTSDBACE1SIRT2 | |
| SCHEMBL6559265 | 0.96 | TRPV1 (0.38) | TRPV1KCNA5CTSDBACE1SIRT2 | |
| SCHEMBL6559522 | 0.90 | TRPV1 (0.40) | TRPV1KCNA5CTSDBACE1SIRT2 | |
| SCHEMBL6559514 | 0.86 | TRPV1 (0.39) | TRPV1KCNA5CTSDBACE1SIRT2 | |
| SCHEMBL6558219 | 0.86 | TRPV1 (0.39) | TRPV1KCNA5CTSDBACE1SIRT2 | |
| SCHEMBL6558672 | 0.83 | TRPV1 (0.49) | TRPV1CTSDBACE1 | |
| SCHEMBL6559931 | 0.81 | KCNA5 (0.44) | TRPV1KCNA5CTSDBACE1SIRT2 | |
| SCHEMBL6558681 | 0.81 | KCNA5 (0.42) | TRPV1KCNA5CTSDBACE1SIRT2 | |
| SCHEMBL6559240 | 0.80 | KCNE1 (0.44) | SIRT2CYP1A2CYP2C19SIRT1KDM4E | |
| SCHEMBL6559929 | 0.79 | SIRT2 (0.38) | TRPV1CTSDBACE1SIRT2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |