Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 16/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560424 | 0.87 | MTNR1A (0.65) | MTNR1AMTNR1B | |
| SCHEMBL6559745 | 0.85 | MTNR1A (0.64) | MTNR1AMTNR1BALDH1A1NQO2 | |
| SCHEMBL6248773 | 0.84 | MTNR1A (0.75) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL6559762 | 0.83 | MTNR1A (0.62) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL6560401 | 0.80 | MTNR1A (0.74) | MTNR1AMTNR1BALDH1A1NQO2 | |
| SCHEMBL6246356 | 0.80 | MTNR1A (0.80) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8961088 | 0.78 | MTNR1A (0.78) | MTNR1AMTNR1BALDH1A1NQO2 | |
| SCHEMBL8961043 | 0.78 | MTNR1A (0.78) | MTNR1AMTNR1BALDH1A1NQO2 | |
| SCHEMBL6247137 | 0.78 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL29493844 | 0.78 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837850-B1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-09-01 | — | — | EP | disclosed |
| US-5708005-A | MELATONIN RECEPTOR BINDERS, SLEEP DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-13 | — | — | US | disclosed |
| WO-1997001539-A1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-16 | — | — | WO | disclosed |