Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29859779 | 1.00 | TSHR (0.47) | TSHRALDH1A1KDM4EGLAGAA | |
| SCHEMBL31261177 | 0.90 | TSHR (0.44) | TSHRALDH1A1KDM4EGLAGAA | |
| SCHEMBL28080391 | 0.90 | KDM4E (0.49) | TSHRALDH1A1KDM4EGLAGAA | |
| SCHEMBL23500733 | 0.90 | CYP2C9 (0.47) | TSHRALDH1A1KDM4EGLAGAA | |
| SCHEMBL31261191 | 0.87 | TSHR (0.42) | TSHRALDH1A1KDM4EGLAGAA | |
| SCHEMBL28593529 | 0.86 | TSHR (0.51) | TSHRALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10465834 | 0.85 | CYP2C19 (0.53) | TSHRALDH1A1MEN1KMT2ACA12 | |
| SCHEMBL29897883 | 0.85 | TSHR (0.46) | TSHRALDH1A1KDM4EGLAGAA | |
| SCHEMBL6559833 | 0.85 | TSHR (0.46) | TSHRALDH1A1KDM4EGLAGAA | |
| SCHEMBL20399682 | 0.85 | JMJD6 (0.43) | ALDH1A1KDM4EGLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118480002-A | High-selectivity synthesis method of imazamox intermediate diethyl 5-bromomethyl-2, 3-pyridine dicarboxylic acid | 湖北三峡实验室 | 2024-08-13 | — | — | CN | claimed |
| CN-220939170-U | Rectifying device for production and processing of 5-methyl-pyridine-2, 3-dicarboxylic acid diethyl ester | 武威昌鸿科技有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-220589956-U | Layered processing reaction kettle for producing 5-methyl-pyridine-2, 3-dicarboxylic acid diethyl ester | 武威昌鸿科技有限公司 | 2024-03-15 | — | — | CN | claimed |
| CN-112142727-B | Imazapyr methyl intermediate and preparation method and application thereof | 山东润博生物科技有限公司 | 2022-09-16 | — | — | CN | claimed |
| CN-114933561-A | Preparation method of 5-substituted-2, 3-pyridine dicarboxylic ester compound and quaternary ammonium salt thereof | 沈阳万菱生物技术有限公司 | 2022-08-23 | — | — | CN | claimed |
| CN-112142727-A | Imazapyr methyl intermediate and preparation method and application thereof | 山东润博生物科技有限公司 | 2020-12-29 | — | — | CN | claimed |
| EP-0461402-B1 | Process for the preparation of substituted and unsubstituted 2,3-pyridinedicarboxylates from chloromaleate or chlorofumarate or mixtures thereof | AMERICAN CYANAMID CO (US) | 1998-07-15 | — | — | EP | claimed |
| CN-1038507-C | Process for preparation of substituted and unsubstituted-2,3-pyridinedicarboxylates from chloromaleate or chlorofumarate or mixtures thereof | AMERICAN CYANAMID CO (US) | 1998-05-27 | — | — | CN | claimed |
| CN-1038414-C | Process for preparation of dialkyl, pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichlorosucciate | AMERICAN CYANAMID CO (US) | 1998-05-20 | — | — | CN | claimed |
| EP-0548522-B1 | Process for the purification of 2,3-pyridine and quinolinedicarboxylic acid diester compounds | AMERICAN CYANAMID CO (US) | 1997-01-29 | — | — | EP | claimed |
| EP-0461403-A1 | Process for the preparation of dialkyl pyridine-2,3-dicarboxylate and derivatives thereof from dialkyl dichlorosucciante | AMERICAN CYANAMID COMPANY (US) | 1991-12-18 | — | — | EP | claimed |
| EP-0461401-A1 | Process for the preparation of dialkyl, pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate | AMERICAN CYANAMID COMPANY (US) | 1991-12-18 | — | — | EP | claimed |
| EP-0456504-A2 | Process for preparing pyridinecarboxylic acid derivatives | HOECHST CELANESE CORPORATION (US) | 1991-11-13 | — | — | EP | claimed |
| US-5047542-A | Reaction of ketoester with unsaturated aldehyde or ketone | HOECHST CELANESE CORPORATION (US) | 1991-09-10 | — | — | US | claimed |
| EP-0415767-A2 | Process for preparing pyridine carboxylic acid derivatives | HOECHST CELANESE CORPORATION (US) | 1991-03-06 | — | — | EP | claimed |
| EP-0220518-B1 | PREPARATION OF SUBSTITUTED AND DISUBSTITUTED PYRIDINE-2,3-DICARBOXYLATE ESTERS | AMERICAN CYANAMID COMPANY (US) | 1991-02-06 | — | — | EP | claimed |
| US-4871859-A | REACTING KETOESTER WITH UNSATURATED ALDEHYDE OR KETONE AND AMMONIUM SALT IN SOLVENT AND DEHYDROGENATION CATALYST | HOECHST CELANESE CORPORATION | 1989-10-03 | — | — | US | claimed |
| WO-1989008103-A1 | PROCESS FOR PREPARING PYRIDINE CARBOXYLIC ACID ESTERS | HOECHST CELANESE CORPORATION (US) | 1989-09-08 | — | — | WO | claimed |
| US-4723011-A | ALPHA-HALO-BETA-KETOESTERS, ALPHA, BETA UNSATURATED KETONE OR ALDEHYDE, AMMONIUM SALT | AMERICAN CYANAMID COMPANY (US) | 1988-02-02 | — | — | US | claimed |
| EP-0220518-A2 | Preparation of substituted and disubstituted pyridine-2,3-dicarboxylate esters | AMERICAN CYANAMID COMPANY (US) | 1987-05-06 | — | — | EP | claimed |