Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 13/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 13/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559279 | 0.90 | KCNE1 (0.41) | KCNE1KCNQ1HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6559524 | 0.84 | KCNE1 (0.57) | KCNE1KCNQ1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6601927 | 0.84 | KCNE1 (0.39) | KCNE1KCNQ1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6558707 | 0.83 | KCNE1 (0.45) | KCNE1KCNQ1HTR2BSIGMAR1HTR1A | |
| SCHEMBL6558501 | 0.83 | KCNE1 (0.45) | KCNE1KCNQ1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6559211 | 0.82 | KCNE1 (0.44) | KCNE1KCNQ1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6601004 | 0.82 | KCNE1 (0.46) | KCNE1KCNQ1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6559329 | 0.82 | KCNE1 (0.44) | KCNE1KCNQ1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6601126 | 0.82 | KCNE1 (0.68) | KCNE1KCNQ1HTR2BTMEM97SIGMAR1 | |
| SCHEMBL6558631 | 0.81 | KCNE1 (0.46) | KCNE1KCNQ1HTR2BSIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |