Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NAMPT | P43490 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.50 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996878 | 0.88 | NAMPT (0.78) | POLBNAMPTSCDJAK2TYK2 | |
| SCHEMBL2790938 | 0.85 | POLB (0.64) | POLBNAMPTRAB9ASCDJAK2 | |
| SCHEMBL6557916 | 0.84 | POLB (0.55) | POLBNAMPTRAB9ASCDJAK2 | |
| SCHEMBL6558125 | 0.84 | POLB (0.55) | POLBNAMPTRAB9ASCDSMN1; SMN2 | |
| SCHEMBL6558086 | 0.82 | POLB (0.52) | POLBNAMPTRAB9ASMN1; SMN2ROCK2 | |
| SCHEMBL2793871 | 0.81 | POLB (0.59) | POLBNAMPTSCDJAK2TYK2 | |
| SCHEMBL2793874 | 0.81 | POLB (0.59) | POLBNAMPTSCDJAK2TYK2 | |
| SCHEMBL6558160 | 0.81 | POLB (0.58) | POLBNAMPTSCDJAK2TYK2 | |
| SCHEMBL2818520 | 0.81 | POLB (0.58) | POLBNAMPTSCDJAK2TYK2 | |
| SCHEMBL2851561 | 0.80 | LMNA (0.61) | SMN1; SMN2HDAC1HDAC2HDAC3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391454-A1 | Substituted benzamide compounds with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-0757038-B1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-11-26 | — | — | EP | disclosed |
| EP-1195372-A1 | N-heterocyclic substituted benzamide derivatives with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6156766-A | Benzamide compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| US-5958944-A | TREATMENT OF CIRCULATORY DISEASES IN CORONARY, CEREBRAL, RENAL AND PERIPHERAL ARTERIES, AS A THERAPEUTIC AGENT FOR HYPERTENSION, ANGINA PECTORIS, AND RENAL AND PERIPHERAL CIRCULATION DISORDER, ANTIASTHMATIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0757038-A1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |