SCHEMBL6560656

SCHEMBL6560656

CCCc1c(OCCCSc2ccc(CC(=O)OC)cc2Cl)ccc2c(CC)coc12

nearest known ligand 0.85

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 15/20 0.85
PPARG P37231 13/20 0.85
PPARA Q07869 13/20 0.85
NR1H2 P55055 6/20 0.58
NR1H3 Q13133 6/20 0.58
PDE5A O76074 3/20 0.37
TP53 P04637 1/20 0.35
MAPT P10636 1/20 0.35
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6561585 0.92 PPARD (1.00) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6561754 0.90 PPARD (0.69) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6559855 0.89 PPARD (0.87) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6559861 0.89 PPARD (0.67) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL7040035 0.85 PPARD (0.85) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL7044857 0.85 PPARD (0.78) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL7040439 0.85 PPARD (0.71) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL7041349 0.84 PPARD (0.70) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6559721 0.84 PPARD (0.60) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6561590 0.82 PPARD (0.82) PPARDPPARGPPARANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0904079-B1 ANTIDIABETIC AGENTS MERCK & CO INC (US) 2004-03-24 EP disclosed
EP-0904079-A4 1999-05-06 EP disclosed
EP-0904079-A1 ANTIDIABETIC AGENTS Merck & Co., Inc. (US) 1999-03-31 EP disclosed
US-5859051-A ACETYLPHENOL DERIVATIVES MERCK & CO., INC. (US) 1999-01-12 US disclosed
WO-1997027857-A1 ANTIDIABETIC AGENTS MERCK & CO., INC. (US) 1997-08-07 WO disclosed