SCHEMBL6560810

SCHEMBL6560810

Oc1ccccc1-c1n[nH]c(-c2ccccc2)n1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.76
NR1H2 P55055 7/20 0.65
NR1H3 Q13133 7/20 0.65
HPGDS O60760 1/20 0.58
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
LMNA P02545 1/20 0.54
DGAT1 O75907 1/20 0.54
SMN1; SMN2 Q16637 3/20 0.53
HPGD P15428 3/20 0.53
CYP1A2 P05177 2/20 0.53
TP53 P04637 1/20 0.53
ALPL P05186 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
ALDH1A1 P00352 3/20 0.51
TSHR P16473 2/20 0.51
MEN1 O00255 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1528343 0.87 ADORA2A (0.77) ADORA2ANR1H2NR1H3NPC1RAB9A
SCHEMBL1528413 0.86 ADORA2A (1.00) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL12171144 0.84 ADORA2A (0.59) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL27803661 0.79 NR1H2 (0.51) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL646494 0.79 NR1H2 (0.76) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL28148107 0.79 NR1H2 (0.65) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL666693 0.79 NR1H2 (1.00) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL6561348 0.79 NR1H2 (0.59) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL1071190 0.77 NR1H2 (0.96) ADORA2ANR1H2NR1H3HPGDSNPC1
SCHEMBL17574086 0.77 NR1H2 (0.96) ADORA2ANR1H2NR1H3HPGDSNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1071670-B1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA (DE) 2004-07-07 EP disclosed
US-6255327-B1 ANTIHYPOXC, ANTIISCHEMIC AGENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-07-03 US disclosed
EP-1071670-A1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM KG (DE) 2001-01-31 EP disclosed
WO-1999054314-A1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-10-28 WO disclosed