SCHEMBL6561077

SCHEMBL6561077

O=[C]NCCc1ccc(Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.55
CYP1A2 P05177 3/20 0.47
CYP2D6 P10635 3/20 0.47
CNR1 P21554 3/20 0.47
CYP2C19 P33261 2/20 0.47
IDO1 P14902 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
GAA P10253 2/20 0.45
MAPT P10636 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
GFER P55789 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
LMNA P02545 2/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA4 P22748 1/20 0.44
CA9 Q16790 1/20 0.44
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6562213 0.79 ALDH1A1 (0.50) TAAR1CYP1A2CNR1MAPTNPC1
SCHEMBL2701813 0.79 TMEM97 (0.55) TAAR1CYP1A2CYP2D6CYP2C19L3MBTL1
SCHEMBL28849471 0.79 GFER (0.52) GFERCA12CA1CA2CA9
SCHEMBL350048 0.79 TAAR1 (0.55) TAAR1CYP1A2CYP2D6CYP2C19L3MBTL1
SCHEMBL349780 0.78 ALDH1A1 (0.52) TAAR1CYP1A2CYP2D6CYP2C19IDO1
SCHEMBL350152 0.78 MEN1 (0.52) CYP2C19IDO1NPC1RAB9ASMN1; SMN2
SCHEMBL5420659 0.76 FFAR1 (0.48) TAAR1CNR1GAALMNAMEN1
SCHEMBL6562364 0.76 KCNJ1 (0.50) CNR1MAPTCA12CA1CA2
SCHEMBL1302121 0.75 TDP1 (0.46) L3MBTL1NPC1RAB9ASMN1; SMN2LMNA
SCHEMBL5681339 0.75 TAAR1 (0.67) TAAR1CYP1A2CYP2D6CNR1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4716162-A BRAIN FUNCTION SANKYO COMPANY, LIMITED (JP) 1987-12-29 US claimed
EP-1085009-B1 INDAN DERIVATIVES NISSAN CHEMICAL IND LTD (JP) 2004-11-10 EP disclosed
EP-0934296-B1 CHROMAN DERIVATIVES NISSAN CHEMICAL IND LTD (JP) 2003-06-04 EP disclosed
US-6486178-B1 Indane derivatives NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2002-11-26 US disclosed
EP-1085009-A1 INDAN DERIVATIVES Nissan Chemical Industries, Ltd. (JP) 2001-03-21 EP disclosed
US-6066631-A Chroman derivatives NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2000-05-23 US disclosed
WO-2000012492-A1 BENZOXAZINE DERIVATIVES NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2000-03-09 WO disclosed
EP-0934296-A1 CHROMAN DERIVATIVES NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1999-08-11 EP disclosed
WO-1998004542-A1 CHROMAN DERIVATIVES NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-02-05 WO disclosed
EP-0171217-B1 FUSED-RING HETEROCYCLIC COMPOUNDS A PROCESS FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE SANKYO COMPANY LIMITED (JP) 1989-05-03 EP disclosed
US-4716162-A BRAIN FUNCTION SANKYO COMPANY, LIMITED (JP) 1987-12-29 US disclosed
EP-0171217-A2 Fused-ring heterocyclic compounds a process for their production and their pharmaceutical use SANKYO COMPANY LIMITED (JP) 1986-02-12 EP disclosed