Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748217 | 0.86 | MAPT (0.51) | MAPTHPGDL3MBTL1MAPK1KMT2A | |
| SCHEMBL9324460 | 0.83 | MAPT (0.45) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL17087123 | 0.81 | MAPT (0.53) | MAPTHPGDL3MBTL1MAPK1KMT2A | |
| SCHEMBL7266985 | 0.81 | KMT2A (0.46) | MAPTHPGDL3MBTL1MAPK1KMT2A | |
| SCHEMBL2799797 | 0.81 | MAPT (0.53) | MAPTHPGDL3MBTL1MAPK1KMT2A | |
| SCHEMBL660641 | 0.79 | MAPT (0.51) | MAPTHPGDL3MBTL1MAPK1KMT2A | |
| SCHEMBL12243847 | 0.79 | MAPT (0.56) | MAPTHPGDL3MBTL1MAPK1KMT2A | |
| SCHEMBL8408395 | 0.79 | HPGD (0.41) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL5592615 | 0.78 | KMT2A (0.46) | MAPTL3MBTL1KMT2AMEN1KDM4E | |
| SCHEMBL2376058 | 0.78 | MAPT (0.54) | MAPTHPGDL3MBTL1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |