Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380211 | 0.94 | MAPT (0.53) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL660641 | 0.90 | MAPT (0.51) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL2476789 | 0.83 | MAPT (0.46) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL12243847 | 0.82 | MAPT (0.56) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL4054790 | 0.82 | HPGD (0.41) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL10359370 | 0.81 | KDM4E (0.59) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL11705523 | 0.80 | PLAU (0.43) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL13313280 | 0.80 | KMT2A (0.59) | MAPTHPGDL3MBTL1MAPK1KDM4E | |
| SCHEMBL27574370 | 0.80 | KDM4E (0.50) | MAPTL3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL3002181 | 0.79 | SMN1; SMN2 (0.37) | MAPTHPGDL3MBTL1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376473-A1 | 3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Merck Canada Inc. (CA) | 2011-10-19 | — | — | EP | disclosed |
| US-20110237622-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2011-09-29 | — | — | US | disclosed |
| US-20100280024-A1 | RENIN INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2010-11-04 | — | — | US | disclosed |
| EP-2205559-A1 | RENIN INHIBITORS | Cadila Healthcare Limited (IN) | 2010-07-14 | — | — | EP | disclosed |
| WO-2010066028-A1 | 3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-06-17 | — | — | WO | disclosed |
| WO-2009087649-A1 | RENIN INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237622-A1 | RENIN INHIBITORS | REN, ACE, ACE2 | MAPT 4520/4885HPGD 115/4885L3MBTL1 4872/4885 |
| US-20100280024-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MAPT 45/4885HPGD 599/4885L3MBTL1 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.