Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.52 |
| ▸ | DRD3 | P35462 | 7/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6253652 | 0.89 | GRIN2B (0.44) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL4106723 | 0.88 | HTR1D (0.70) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL4100215 | 0.88 | HTR1D (0.70) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL9776820 | 0.88 | DRD2 (0.70) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8692261 | 0.80 | DRD2 (0.78) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL8693876 | 0.79 | DRD2 (0.76) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL1792787 | 0.78 | GRIN2B (0.61) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8689197 | 0.78 | DRD2 (0.79) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL8689152 | 0.78 | DRD2 (0.50) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL14515547 | 0.77 | PSEN1 (0.40) | DRD2DRD3DRD4SIGMAR1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |