Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.74 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.74 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 12/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190975 | 1.00 | KCNH2 (0.74) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9435683 | 0.92 | MEN1 (0.72) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10679416 | 0.92 | MEN1 (0.72) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9875522 | 0.90 | KCNH2 (0.60) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9209179 | 0.90 | KCNH2 (0.60) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10679566 | 0.88 | KCNH2 (0.57) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10686830 | 0.86 | CACNA1F (0.54) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10680718 | 0.85 | POLB (0.54) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| Sparfloxacin SCHEMBL41311 | 0.85 | KCNH2 (1.00) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| Sparfloxacin SCHEMBL1387460 | 0.85 | KCNH2 (1.00) | KCNH2POLBCACNA1FMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408034-A1 | Use of Quinoline derivatives as antibacterial agents | Schulz & Schlimbach GbR (DE) | 2004-04-14 | — | — | EP | claimed |
| EP-1244434-B1 | USE OF CHEMOTHERAPEUTIC AGENTS | SCHULZ & SCHLIMBACH GBR (DE) | 2004-03-17 | — | — | EP | claimed |
| EP-1244434-A2 | USE OF CHEMOTHERAPEUTIC AGENTS | Schulz, Hans-Herrmann (DE) | 2002-10-02 | — | — | EP | claimed |
| WO-2001045679-A2 | USE OF CHEMOTHERAPEUTIC AGENTS FOR TOPICAL TREATMENT | SCHULZ HANS HERRMANN (DE) | 2001-06-28 | — | — | WO | claimed |
| EP-0342649-B1 | Improved process for the preparation of 5-amino-7-(substituted amino)-quinoline-3-carboxylic acids | WARNER LAMBERT CO (US) | 1994-11-30 | — | — | EP | claimed |
| EP-0409254-B1 | RAPID-RELEASING ORAL PARTICLE PHARMACEUTICAL PREPARATION WITH UNPLEASANT TASTE MASKED | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | claimed |
| EP-1408034-A1 | Use of Quinoline derivatives as antibacterial agents | Schulz & Schlimbach GbR (DE) | 2004-04-14 | — | — | EP | disclosed |
| EP-1244434-A2 | USE OF CHEMOTHERAPEUTIC AGENTS | Schulz, Hans-Herrmann (DE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001045679-A2 | USE OF CHEMOTHERAPEUTIC AGENTS FOR TOPICAL TREATMENT | SCHULZ HANS HERRMANN (DE) | 2001-06-28 | — | — | WO | disclosed |
| EP-0284935-A1 | 5-Substituted quinolone- and naphthyridone carboxylic acid derivatives | BAYER AG (DE) | 1988-10-05 | — | — | EP | disclosed |