Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | IAPP | P10997 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAPDH | P04406 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8680504 | 0.88 | TAAR1 (0.65) | TAAR1HTR2CHMGB1MEN1RAD52 | |
| SCHEMBL31290573 | 0.88 | IAPP (0.44) | IAPPHTR1ABIDMCL1BCL2L1 | |
| SCHEMBL218408 | 0.88 | IAPP (0.44) | IAPPHTR1ABIDMCL1BCL2L1 | |
| SCHEMBL27589437 | 0.86 | BID (0.51) | TAAR1KDM4EMAPTALOX15HSD17B10 | |
| SCHEMBL11833247 | 0.86 | BID (0.51) | TAAR1KDM4EMAPTALOX15HSD17B10 | |
| SCHEMBL31737937 | 0.83 | TAAR1 (0.44) | TAAR1IAPPHTR1AKDM4EMAPT | |
| SCHEMBL28788486 | 0.83 | BID (0.50) | IAPPKDM4EMAPTALOX15HSD17B10 | |
| SCHEMBL983928 | 0.82 | GABRA1 (0.52) | IAPPHTR1ABIDMCL1BCL2L1 | |
| SCHEMBL3670450 | 0.81 | TAAR1 (0.45) | TAAR1HMGB1MAPT | |
| SCHEMBL1796696 | 0.81 | IAPP (0.42) | IAPPHTR1AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |