SCHEMBL6561687

SCHEMBL6561687

CC(C)SCC[C@H](N)C(O)C(=O)NNc1cccc2ccccc12

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 20/20 0.77
METAP1 P53582 17/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6478496 1.00 METAP2 (0.77) METAP2METAP1
SCHEMBL6477355 0.87 METAP2 (1.00) METAP2METAP1
SCHEMBL6489444 0.83 METAP2 (0.67) METAP2METAP1
SCHEMBL6486721 0.81 METAP2 (1.00) METAP2METAP1
SCHEMBL6478655 0.81 METAP2 (1.00) METAP2METAP1
SCHEMBL6477700 0.80 METAP2 (1.00) METAP2METAP1
SCHEMBL6489865 0.80 METAP2 (0.83) METAP2METAP1
SCHEMBL6477143 0.76 METAP2 (0.80) METAP2METAP1
SCHEMBL6477252 0.76 METAP2 (0.66) METAP2METAP1
SCHEMBL6484232 0.75 METAP2 (1.00) METAP2METAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1272456-B1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2004-10-27 EP claimed