Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561794 | 1.00 | PLK1 (0.55) | PLK1MMP3HDAC8SMN1; SMN2NR4A1 | |
| SCHEMBL6561799 | 1.00 | PLK1 (0.55) | PLK1MMP3HDAC8SMN1; SMN2NR4A1 | |
| SCHEMBL6562099 | 0.85 | PLK1 (0.41) | PLK1SMN1; SMN2NPC1RAB9ACYP3A4 | |
| SCHEMBL6563238 | 0.85 | PLK1 (0.41) | PLK1SMN1; SMN2NPC1RAB9ACYP3A4 | |
| SCHEMBL6562104 | 0.85 | PLK1 (0.41) | PLK1SMN1; SMN2NPC1RAB9ACYP3A4 | |
| SCHEMBL6563179 | 0.83 | PLK1 (0.53) | PLK1MMP3HDAC8NR4A1NR4A2 | |
| SCHEMBL6563174 | 0.83 | PLK1 (0.53) | PLK1MMP3HDAC8NR4A1NR4A2 | |
| SCHEMBL6561880 | 0.79 | PLK1 (0.48) | PLK1MMP3HDAC8SMN1; SMN2NR4A1 | |
| SCHEMBL6560724 | 0.79 | PLK1 (0.48) | PLK1MMP3HDAC8SMN1; SMN2NR4A1 | |
| SCHEMBL6561900 | 0.79 | NPC1 (0.51) | PLK1SMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944581-A4 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | LILLY CO ELI (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-0944581-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998022429-A1 | PROCESS OF PREPARING SUBSTITUTED ACRYLAMIDES | ELI LILLY AND COMPANY (US) | 1998-05-28 | — | — | WO | disclosed |