Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27474439 | 0.84 | MAPT (0.68) | GRM5 | |
| SCHEMBL2858001 | 0.84 | GRM5 (0.70) | GRM5LMNA | |
| SCHEMBL2482825 | 0.81 | GRM5 (1.00) | GRM5LMNA | |
| SCHEMBL2569658 | 0.81 | F2 (0.60) | GRM5LMNA | |
| SCHEMBL2551230 | 0.77 | KLK3 (0.52) | GRM5 | |
| SCHEMBL2562097 | 0.77 | KLKB1 (0.57) | — | |
| SCHEMBL26673912 | 0.76 | MAPT (0.62) | GRM5 | |
| SCHEMBL2563531 | 0.76 | F2 (0.59) | GRM5LMNAADORA1 | |
| SCHEMBL2563383 | 0.76 | F2 (0.72) | GRM5LMNA | |
| SCHEMBL2555846 | 0.76 | F2 (0.57) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788358-B1 | USE OF PYRAZOLE COMPOUNDS FOR THE TREATMENT OF GLOMERULONEPHRITIS, CANCER, ATHEROSCLEROSIS OR RESTENOSIS | MILLENNIUM PHARM INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5916908-A | Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases | COR THERAPEUTICS, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0788358-A2 | PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996014843-A2 | PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1996-05-23 | — | — | WO | disclosed |