Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 6/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 11/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30493558 | 0.81 | ADRB2 (0.58) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL6925186 | 0.81 | ADRB2 (0.58) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL6112126 | 0.80 | ADRB2 (0.64) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL4627007 | 0.80 | ADRB2 (0.60) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL1732912 | 0.79 | TLR4 (0.54) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL30692087 | 0.78 | ADRB2 (0.59) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL14046114 | 0.78 | ADRB2 (0.61) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL6472027 | 0.78 | ADRB2 (0.58) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL6074582 | 0.78 | ADRB2 (0.67) | TLR4ADRB2DNM1ADRB1ADRB3 | |
| SCHEMBL5694608 | 0.78 | ADRB2 (0.67) | TLR4ADRB2DNM1ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098646-B1 | STABILIZED CARVEDILOL INJECTION SOLUTION | ROCHE DIAGNOSTICS GMBH (DE) | 2004-09-22 | — | — | EP | disclosed |
| US-6664284-B2 | Ready-to-inject; buffer with pH of 7.2 to 4.0, a water-soluble organic solvent, an antioxidant and an agent which binds heavy metal ions | ROCHE DIAGNOSTICS GMBH (DE) | 2003-12-16 | — | — | US | disclosed |
| US-20020169199-A1 | Stabilized carvedilol injection solution | GRUBER WERNER (DE) | 2002-11-14 | — | — | US | disclosed |
| EP-1098646-A1 | STABILIZED CARVEDILOL INJECTION SOLUTION | Roche Diagnostics GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004902-A1 | STABILIZED CARVEDILOL INJECTION SOLUTION | ROCHE DIAGNOSTICS GMBH (DE) | 2000-02-03 | — | — | WO | disclosed |