Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.58 |
| ▸ | PGR | P06401 | 3/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343098 | 1.00 | HIF1A (0.64) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL13517833 | 0.89 | HIF1A (0.53) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL13517831 | 0.89 | HIF1A (0.53) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL13518091 | 0.89 | HIF1A (0.53) | HIF1ANR3C1LMNAMEN1MAPT | |
| Cismadinone SCHEMBL2111096 | 0.88 | HIF1A (0.52) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL8331404 | 0.87 | CYP3A4 (0.62) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL7794907 | 0.87 | CYP3A4 (0.62) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL7796325 | 0.86 | CYP3A4 (0.76) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL18351253 | 0.86 | CYP3A4 (0.76) | HIF1ANR3C1LMNAMEN1MAPT | |
| SCHEMBL7796323 | 0.86 | CYP3A4 (0.76) | HIF1ANR3C1LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828120-B2 | Preparation of 11 beta ,17 alpha ,21- trihydroxy-6 alpha -methylpregna-1,4-diene-3,20-dione 21-acetate; obtain chemical intermediates, incubate reaction mix and enzymes, recover product | PHARMACIA AND UPJOHN COMPANY | 2004-12-07 | — | — | US | claimed |
| EP-1399463-A1 | PROCESS TO PREPARE 11$g(b),17$g(a),21-TRIHYDROXY-6$g(a)-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-24 | — | — | EP | claimed |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CRIA, INC. | 2003-03-06 | — | — | US | claimed |
| WO-2002102826-A1 | PROCESS TO PREPARE 11β,17α,21-TRIHYDROXY-6α-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-27 | — | — | WO | claimed |
| US-6828120-B2 | Preparation of 11 beta ,17 alpha ,21- trihydroxy-6 alpha -methylpregna-1,4-diene-3,20-dione 21-acetate; obtain chemical intermediates, incubate reaction mix and enzymes, recover product | PHARMACIA AND UPJOHN COMPANY | 2004-12-07 | — | — | US | disclosed |
| EP-1399463-A1 | PROCESS TO PREPARE 11$g(b),17$g(a),21-TRIHYDROXY-6$g(a)-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-24 | — | — | EP | disclosed |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CRIA, INC. | 2003-03-06 | — | — | US | disclosed |
| WO-2002102826-A1 | PROCESS TO PREPARE 11β,17α,21-TRIHYDROXY-6α-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-27 | — | — | WO | disclosed |
| EP-0941361-B1 | A METHOD FOR THE PREPARATION OF STEROID COMPOUNDS | DURAMED EUROP LTD (GB) | 2001-11-28 | — | — | EP | disclosed |
| EP-0941361-A1 | A METHOD FOR THE PREPARATION OF STEROID COMPOUNDS | Duramed Europe Limited (GB) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998020151-A1 | A METHOD FOR THE PREPARATION OF STEROID COMPOUNDS | DURAMED EUROPE LIMITED (GB) | 1998-05-14 | — | — | WO | disclosed |
| EP-0422100-B1 | 11 BETA-SUBSTITUTED PROGESTERONE ANALOGS | RES TRIANGLE INST (US) | 1997-03-12 | — | — | EP | disclosed |
| EP-0422100-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| US-5073548-A | Antiprogestational, progestational and antiglucocorticoid activity; glandular disorders; vision defects; antifertility agents | RESEARCH TRIANGLE INSTITUTE (US) | 1991-12-17 | — | — | US | disclosed |
| EP-0422100-A1 | 11-g(b)-SUBSTITUTED PROGESTERONE ANALOGS. | RES TRIANGLE INST (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4954490-A | HORMONE INHIBITORS | RESEARCH TRIANGLE INSTITUTE (US) | 1990-09-04 | — | — | US | disclosed |
| WO-1989012448-A1 | 11beta-SUBSTITUTED PROGESTERONE ANALOGS | RESEARCH TRIANGLE INSTITUTE (US) | 1989-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CYP17A1, CYP51A1, HSD17B11 | HIF1A 584/4885NR3C1 103/4885LMNA 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.