SCHEMBL6563402

SCHEMBL6563402

CCOCOc1ccc(-c2sc3cc(OCOCC)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 18/20 0.78
ESR2 Q92731 17/20 0.78
ENPP3 O14638 2/20 0.75
MEN1 O00255 2/20 0.74
ALDH1A1 P00352 2/20 0.74
LMNA P02545 2/20 0.74
TP53 P04637 2/20 0.74
CYP3A4 P08684 2/20 0.74
MAPT P10636 2/20 0.74
ALOX15 P16050 2/20 0.74
KMT2A Q03164 2/20 0.74
HSD17B10 Q99714 2/20 0.74
TDP1 Q9NUW8 2/20 0.74
PLD2 O14939 1/20 0.74
KDM1A O60341 1/20 0.74
NR1I2 O75469 1/20 0.74
USP2 O75604 1/20 0.74
C5 P01031 1/20 0.74
FYN P06241 1/20 0.74
PGR P06401 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6565321 0.99 ESR1 (0.79) ESR1ESR2ENPP3MEN1ALDH1A1
SCHEMBL11209650 0.94 ESR1 (0.82) ESR1ESR2ENPP3MEN1ALDH1A1
SCHEMBL6564836 0.92 ESR1 (0.83) ESR1ESR2ENPP3MEN1ALDH1A1
Hydrochloric Acid SCHEMBL6564916 0.91 ESR1 (0.83) ESR1ESR2ENPP3MEN1ALDH1A1
SCHEMBL11551267 0.91 ESR1 (0.81) ESR1ESR2ENPP3MEN1ALDH1A1
SCHEMBL1680060 0.90 ESR1 (0.90) ESR1ESR2ENPP3MEN1ALDH1A1
Bromide SCHEMBL1680033 0.89 ESR1 (0.88) ESR1ESR2ENPP3MEN1ALDH1A1
SCHEMBL11551601 0.89 ESR1 (0.75) ESR1ESR2ENPP3MEN1ALDH1A1
SCHEMBL11188522 0.88 ESR1 (0.90) ESR1ESR2ENPP3MEN1ALDH1A1
SCHEMBL11547499 0.88 ESR1 (0.74) ESR1ESR2ENPP3MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1025098-B1 BENZOTHIOPHENES LILLY CO ELI (US) 2004-03-31 EP claimed
US-6403614-B1 SUCH AS 2-(4-(METHYLTHIOMETHOXY)PHENYL)-3-(4-(2-PIPERIDIN-1-YL)ETHOXY) BENZOYL)-6-METHYLTHIOMETHOXYBENZO(B)THIOPHENE;INHIBITION OF OSTEOPOROSIS, HYPERLIPEDEMIA, CANCER, POSTMENOPAUSAL SYNDROME, ELI LILLY AND COMPANY 2002-06-11 US claimed
US-6403614-B1 SUCH AS 2-(4-(METHYLTHIOMETHOXY)PHENYL)-3-(4-(2-PIPERIDIN-1-YL)ETHOXY) BENZOYL)-6-METHYLTHIOMETHOXYBENZO(B)THIOPHENE;INHIBITION OF OSTEOPOROSIS, HYPERLIPEDEMIA, CANCER, POSTMENOPAUSAL SYNDROME, ELI LILLY AND COMPANY 2002-06-11 US disclosed