Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 11/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | VHL | P40337 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511945 | 0.90 | NR1H3 (0.55) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6513593 | 0.89 | NR1H3 (0.57) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6521358 | 0.89 | NR1H3 (0.57) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6520045 | 0.89 | NR1H3 (0.53) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6515146 | 0.87 | NR1H3 (0.55) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6510639 | 0.84 | NR1H3 (0.61) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6519255 | 0.84 | NR1H3 (0.55) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6566799 | 0.83 | NR1H3 (0.54) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6565734 | 0.81 | NR1H3 (0.55) | NR1H3NR1H2MEN1KMT2ANR1I2 | |
| SCHEMBL6564806 | 0.80 | NR1H3 (0.54) | NR1H3NR1H2MEN1KMT2ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |