Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 15/20 | 0.55 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | VHL | P40337 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564806 | 0.93 | NR1H3 (0.54) | NR1H3CCR5NR1H2MEN1NR1I2 | |
| SCHEMBL6566799 | 0.89 | NR1H3 (0.54) | NR1H3CCR5NR1H2MEN1NR1I2 | |
| SCHEMBL6567271 | 0.89 | NR1H3 (0.52) | NR1H3NR1H2RXRANPC1HPGD | |
| SCHEMBL6521358 | 0.86 | NR1H3 (0.57) | NR1H3CCR5NR1H2MEN1NR1I2 | |
| SCHEMBL6513593 | 0.84 | NR1H3 (0.57) | NR1H3CCR5NR1H2MEN1NR1I2 | |
| SCHEMBL6511945 | 0.84 | NR1H3 (0.55) | NR1H3CCR5NR1H2MEN1NR1I2 | |
| SCHEMBL6513607 | 0.83 | NR1H3 (0.46) | NR1H3CCR5NR1H2MEN1NR1I2 | |
| SCHEMBL6564837 | 0.83 | NR1H3 (0.53) | NR1H3NR1H2RXRA | |
| SCHEMBL6510639 | 0.82 | NR1H3 (0.61) | NR1H3CCR5NR1H2MEN1NR1I2 | |
| SCHEMBL6515146 | 0.82 | NR1H3 (0.55) | NR1H3CCR5NR1H2MEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |