Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 15/20 | 0.49 |
| ▸ | METAP1 | P53582 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487736 | 0.90 | MAPT (0.50) | METAP2METAP1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6476693 | 0.83 | METAP2 (0.46) | METAP2METAP1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6477429 | 0.72 | METAP2 (0.73) | METAP2METAP1 | |
| SCHEMBL6485528 | 0.70 | METAP2 (0.78) | METAP2METAP1 | |
| SCHEMBL6476882 | 0.69 | METAP2 (0.60) | METAP2METAP1 | |
| SCHEMBL6477262 | 0.69 | METAP2 (0.62) | METAP2METAP1MAPT | |
| SCHEMBL6484944 | 0.69 | METAP2 (0.54) | METAP2METAP1 | |
| SCHEMBL6487669 | 0.69 | METAP2 (0.78) | METAP2METAP1 | |
| SCHEMBL6487790 | 0.68 | METAP2 (0.67) | METAP2METAP1 | |
| SCHEMBL6477167 | 0.68 | METAP2 (0.62) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | claimed |