SCHEMBL6565146

SCHEMBL6565146

CCN1CCCC1N(C)S(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Br)c1O

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 20/20 0.66
CXCR1 P25024 6/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6562144 0.99 CXCR2 (0.65) CXCR2CXCR1
SCHEMBL6564964 0.92 CXCR2 (0.53) CXCR2CXCR1
Hydrochloric Acid SCHEMBL6562264 0.91 CXCR2 (0.52) CXCR2CXCR1
SCHEMBL6566236 0.89 CXCR2 (0.58) CXCR2CXCR1
Hydrochloric Acid SCHEMBL6562342 0.88 CXCR2 (0.57) CXCR2CXCR1
SCHEMBL6565138 0.81 CXCR2 (0.54) CXCR2CXCR1
Hydrochloric Acid SCHEMBL6562146 0.81 CXCR2 (0.53) CXCR2CXCR1
SCHEMBL6551450 0.80 CXCR2 (1.00) CXCR2CXCR1
SCHEMBL4587192 0.79 CXCR2 (0.98) CXCR2CXCR1
SCHEMBL4587048 0.79 CXCR2 (0.98) CXCR2CXCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1161232-B1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2004-03-24 EP claimed