SCHEMBL6564964

SCHEMBL6564964

CCN1CCCC1N(C)S(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Cl)c1O

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 20/20 0.53
CXCR1 P25024 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6562264 0.99 CXCR2 (0.52) CXCR2CXCR1
SCHEMBL6566236 0.93 CXCR2 (0.58) CXCR2CXCR1
Hydrochloric Acid SCHEMBL6562342 0.92 CXCR2 (0.57) CXCR2CXCR1
SCHEMBL6565146 0.92 CXCR2 (0.66) CXCR2CXCR1
Hydrochloric Acid SCHEMBL6562144 0.91 CXCR2 (0.65) CXCR2CXCR1
Hydrochloric Acid SCHEMBL7500099 0.85 LMNA (0.41) CXCR2CXCR1
SCHEMBL6564960 0.80 L3MBTL1 (0.50) CXCR2
Hydrochloric Acid SCHEMBL6562268 0.80 L3MBTL1 (0.49) CXCR2
SCHEMBL6563957 0.79 CXCR2 (0.80) CXCR2CXCR1
SCHEMBL6566233 0.74 CXCR2 (0.58) CXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1161232-B1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2004-03-24 EP claimed