Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561824 | 0.89 | MAPT (0.31) | PTPN11MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6564919 | 0.88 | PTPN11 (0.35) | PTPN11ACACBPTGES | |
| SCHEMBL6562056 | 0.87 | MAPT (0.30) | MAPTSMN1; SMN2 | |
| SCHEMBL6563363 | 0.87 | F2 (0.38) | MAPTSMN1; SMN2 | |
| SCHEMBL6563459 | 0.86 | POLB (0.30) | MAPTSMN1; SMN2 | |
| SCHEMBL6563636 | 0.85 | MAPT (0.31) | PTPN11MAPTSMN1; SMN2 | |
| SCHEMBL7674318 | 0.83 | PTPN11 (0.32) | PTPN11ACACB | |
| SCHEMBL6565414 | 0.80 | PTPN11 (0.33) | PTPN11ACACBPTGES | |
| SCHEMBL6565327 | 0.79 | — | — | |
| SCHEMBL6561908 | 0.78 | PTPN11 (0.33) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |