Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 16/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566257 | 0.83 | EPHX2 (0.71) | EPHX2TSHRKDM4EALDH1A1MAPT | |
| SCHEMBL4357793 | 0.82 | EPHX2 (0.70) | EPHX2FAAH | |
| SCHEMBL6567242 | 0.80 | EPHX2 (0.67) | EPHX2MAPTNPSR1 | |
| SCHEMBL4354504 | 0.80 | EPHX2 (0.67) | EPHX2MAPTNPSR1 | |
| SCHEMBL4350925 | 0.80 | EPHX2 (0.67) | EPHX2TSHRMAPTNPSR1RAB9A | |
| SCHEMBL4341293 | 0.80 | EPHX2 (0.67) | EPHX2TSHRRAB9AMAPK1NPC1 | |
| SCHEMBL1420838 | 0.80 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL4000748 | 0.77 | EPHX2 (0.62) | EPHX2TSHRRAB9AMAPK1NPC1 | |
| SCHEMBL8064706 | 0.76 | EPHX2 (0.61) | EPHX2 | |
| SCHEMBL29450618 | 0.75 | EPHX2 (0.66) | EPHX2TSHRALDH1A1NPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |