Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 10/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564837 | 0.91 | NR1H3 (0.53) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6565734 | 0.89 | NR1H3 (0.55) | NR1H3RXRANR1H2NPC1HPGD | |
| SCHEMBL6566796 | 0.85 | NR1H3 (0.53) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6515354 | 0.84 | NR1H3 (0.54) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6515334 | 0.84 | NR1H3 (0.53) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6515000 | 0.83 | NR1H3 (0.51) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6512193 | 0.83 | NR1H3 (0.52) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6566798 | 0.82 | NR1H3 (0.45) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6512217 | 0.81 | NR1H3 (0.56) | NR1H3OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL6564806 | 0.81 | NR1H3 (0.54) | NR1H3RXRANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |