Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491655 | 0.89 | HRH3 (1.00) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL492156 | 0.88 | HRH3 (0.97) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL492227 | 0.83 | HRH3 (0.49) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL6570265 | 0.82 | HRH3 (0.84) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| Pitolisant SCHEMBL5487588 | 0.80 | HRH3 (0.54) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL28671150 | 0.79 | L3MBTL1 (0.50) | HRH3 | |
| SCHEMBL2451795 | 0.78 | HRH1 (0.74) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL18503164 | 0.77 | TDP1 (0.53) | HRH3SIGMAR1 | |
| SCHEMBL18503166 | 0.77 | TDP1 (0.53) | HRH3SIGMAR1 | |
| SCHEMBL18503253 | 0.77 | TDP1 (0.53) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100503-B1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ILE BIOPROJET SOC CIV (FR) | 2004-09-22 | — | — | EP | claimed |