Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 10/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6515334 | 0.94 | NR1H3 (0.53) | NR1H3RXRANR1H2OPRM1OPRD1 | |
| SCHEMBL6512193 | 0.94 | NR1H3 (0.52) | NR1H3RXRANR1H2OPRM1OPRD1 | |
| SCHEMBL6515354 | 0.93 | NR1H3 (0.54) | NR1H3RXRANR1H2OPRM1OPRD1 | |
| SCHEMBL6515000 | 0.90 | NR1H3 (0.51) | NR1H3RXRANR1H2OPRM1OPRD1 | |
| SCHEMBL6515267 | 0.89 | NR1H3 (0.50) | NR1H3RXRANR1H2OPRM1OPRD1 | |
| SCHEMBL6515545 | 0.89 | NR1H3 (0.44) | NR1H3RXRANR1H2OPRM1OPRD1 | |
| SCHEMBL6512217 | 0.89 | NR1H3 (0.56) | NR1H3RXRANR1H2OPRM1OPRD1 | |
| SCHEMBL6521358 | 0.87 | NR1H3 (0.57) | NR1H3RXRANR1H2 | |
| SCHEMBL6512042 | 0.87 | NR1H3 (0.51) | NR1H3OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL6567271 | 0.85 | NR1H3 (0.52) | NR1H3RXRANR1H2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |