SCHEMBL6567176

SCHEMBL6567176

C/C=C/CCc1ccc(C2NC(C)(C)CO2)c(F)c1

nearest known ligand 0.30

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 2/20 0.30
CHRNB1 P11230 2/20 0.30
CHRNB2 P17787 2/20 0.30
SLC6A2 P23975 2/20 0.30
CHRNB4 P30926 2/20 0.30
CHRNA3 P32297 2/20 0.30
CHRNA4 P43681 2/20 0.30
SLC6A3 Q01959 2/20 0.30
CHRNG P07510 1/20 0.30
CHRND Q07001 1/20 0.30
SLC6A4 P31645 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6899373 0.87
SCHEMBL6569281 0.81 CHRNA1 (0.30) CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4
SCHEMBL6569199 0.80 CHRNA1 (0.34) CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4
SCHEMBL20126295 0.73 NR3C2 (0.32)
SCHEMBL20126283 0.68 OPRL1 (0.35)
SCHEMBL12955430 0.67 DAO (0.44) SLC6A2SLC6A3SLC6A4
SCHEMBL19792641 0.67 GPR52 (0.32)
SCHEMBL14220525 0.65 BACE1 (0.40)
SCHEMBL18540056 0.65 HTR2A (0.39)
SCHEMBL6567162 0.63 RARB (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0919536-B1 Fluorine-substituted 4-alkenylbenzoic acid and derivatives thereof, and nematic liquid crystal composition containing cyanophenyl benzoate derivatives and liquid crystal display system using the same DAINIPPON INK & CHEMICALS (JP) 2004-04-07 EP disclosed
US-6693223-B1 STRONG POLAR COMPOUND HAVING LARGE DIELECTRIC ANISOTROPY; EXERTS EXCELLENT THRESHOLD VOLTAGE REDUCING EFFECT; EXCELLENT MISCIBILITY WITH CONVENTIONAL LIQUID CRYSTAL MATERIALS DAINIPPON INK AND CHEMICALS, INC. (JP) 2004-02-17 US disclosed
US-20020053659-A1 Fluorine-substituted-4-alkenylbenzoic acid and derivatives thereof, and nematic liquid crystal composition containing cyanophenyl benzoate derivatives and liquid crystal display system using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2002-05-09 US disclosed
US-6287646-B1 MIXTURES DAINIPPON INK AND CHEMICALS, INC. (JP) 2001-09-11 US disclosed
EP-0919536-A1 Fluorine-substituted 4-alkenylbenzoic acid and derivatives thereof, and nematic liquid crystal composition containing cyanophenyl benzoate derivatives and liquid crystal display system using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1999-06-02 EP disclosed