Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566272 | 0.97 | MEN1 (0.51) | PLA2G2DMEN1HSP90AA1KMT2APPARG | |
| SCHEMBL8630299 | 0.85 | PLA2G2D (0.50) | PLA2G2DMEN1HSP90AA1KMT2APTPN11 | |
| SCHEMBL6564087 | 0.84 | PLA2G2D (0.49) | PLA2G2DMEN1HSP90AA1KMT2APTPN11 | |
| SCHEMBL8629309 | 0.82 | MEN1 (0.53) | PLA2G2DMEN1HSP90AA1KMT2APTPN11 | |
| SCHEMBL8629057 | 0.81 | MEN1 (0.52) | PLA2G2DMEN1HSP90AA1KMT2APPARG | |
| SCHEMBL6566128 | 0.80 | HDAC8 (0.49) | MEN1HSP90AA1KMT2APPARGHDAC8 | |
| SCHEMBL6566120 | 0.79 | HTT (0.59) | MEN1KMT2A | |
| SCHEMBL6567159 | 0.78 | PLA2G2D (0.47) | PLA2G2DMEN1HSP90AA1KMT2AHDAC8 | |
| SCHEMBL8629713 | 0.78 | KMT2A (0.53) | MEN1HSP90AA1KMT2APPARGPPARA | |
| SCHEMBL8628372 | 0.77 | MEN1 (0.52) | MEN1HSP90AA1KMT2APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |