Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629309 | 0.97 | MEN1 (0.53) | PLA2G2DMEN1HSP90AA1KMT2APTPN11 | |
| SCHEMBL6564087 | 0.93 | PLA2G2D (0.49) | PLA2G2DMEN1HSP90AA1KMT2APTPN11 | |
| SCHEMBL8629713 | 0.92 | KMT2A (0.53) | MEN1HSP90AA1KMT2ADHODHHDAC8 | |
| SCHEMBL8628704 | 0.89 | KMT2A (0.53) | MEN1HSP90AA1KMT2AHDAC8 | |
| SCHEMBL8629057 | 0.89 | MEN1 (0.52) | PLA2G2DMEN1HSP90AA1KMT2ADHODH | |
| SCHEMBL6567218 | 0.85 | PLA2G2D (0.48) | PLA2G2DMEN1HSP90AA1KMT2APTPN11 | |
| SCHEMBL6567159 | 0.85 | PLA2G2D (0.47) | PLA2G2DMEN1HSP90AA1KMT2AHDAC8 | |
| SCHEMBL8628372 | 0.85 | MEN1 (0.52) | MEN1HSP90AA1KMT2AHDAC8 | |
| SCHEMBL7744003 | 0.84 | HDAC8 (0.57) | MEN1HSP90AA1KMT2AHDAC8 | |
| SCHEMBL8629707 | 0.82 | MCL1 (0.51) | MEN1HSP90AA1KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |