Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631234 | 0.96 | MAPT (0.57) | MAPTPLA2G4BALDH1A1LMNATDP1 | |
| SCHEMBL7717015 | 0.92 | MAPT (0.51) | MAPTPLA2G4BALDH1A1LMNAKMT2A | |
| SCHEMBL20958135 | 0.91 | MAPT (0.45) | MAPTPLA2G4BESR1ALDH1A1LMNA | |
| SCHEMBL20958109 | 0.91 | MAPT (0.45) | MAPTPLA2G4BESR1ALDH1A1LMNA | |
| SCHEMBL6565692 | 0.90 | MAPT (0.65) | MAPTALDH1A1LMNATDP1MAPK1 | |
| SCHEMBL258799 | 0.89 | ALDH1A1 (0.51) | MAPTPLA2G4BESR1ALDH1A1LMNA | |
| SCHEMBL1589463 | 0.89 | MAPT (0.50) | MAPTALDH1A1LMNATDP1MAPK1 | |
| SCHEMBL21642649 | 0.85 | MAPT (0.46) | MAPTPLA2G4BALDH1A1LMNATDP1 | |
| SCHEMBL16162779 | 0.85 | MAPT (0.47) | MAPTALDH1A1LMNATDP1MAPK1 | |
| SCHEMBL5005582 | 0.84 | MAPT (0.63) | MAPTALDH1A1LMNAMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |