Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 10/20 | 0.57 |
| ▸ | HRH1 | P35367 | 8/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567690 | 0.92 | CCR3 (0.63) | CCR3HRH1HRH3L3MBTL3MBTD1 | |
| SCHEMBL6568902 | 0.88 | HRH1 (0.59) | CCR3HRH1ADRB2MEN1KMT2A | |
| SCHEMBL6569270 | 0.87 | HRH1 (0.58) | CCR3HRH1MEN1KMT2AHRH3 | |
| SCHEMBL6570409 | 0.86 | CCR3 (0.57) | CCR3HRH1HRH3L3MBTL3MBTD1 | |
| SCHEMBL6568389 | 0.85 | CCR3 (0.65) | CCR3HRH1ADRB2MEN1KMT2A | |
| SCHEMBL5417094 | 0.83 | HRH1 (0.61) | CCR3HRH1HRH3KCNH2 | |
| SCHEMBL6569244 | 0.80 | HRH1 (0.59) | CCR3HRH1L3MBTL3L3MBTL1TP53BP1 | |
| SCHEMBL5405625 | 0.80 | HRH1 (0.78) | CCR3HRH1MEN1KMT2AHRH3 | |
| Trifluoroacetic Acid SCHEMBL5407013 | 0.78 | HRH1 (0.50) | CCR3HRH1HRH3KCNH2HSD11B1 | |
| SCHEMBL12146655 | 0.76 | HRH1 (0.42) | CCR3HRH1HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |