Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.59 |
| ▸ | CCR3 | P51677 | 8/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569293 | 0.86 | CCR3 (0.65) | HRH1CCR3KDM4EALDH1A1GAA | |
| SCHEMBL6567690 | 0.85 | CCR3 (0.63) | HRH1CCR3CHRM1MGLLTP53BP1 | |
| SCHEMBL5415084 | 0.82 | HRH1 (0.62) | HRH1CCR3CHRM1KCNH2 | |
| SCHEMBL6568902 | 0.82 | HRH1 (0.59) | HRH1CCR3KDM4EALDH1A1MGLL | |
| SCHEMBL6569270 | 0.81 | HRH1 (0.58) | HRH1CCR3KDM4EALDH1A1GAA | |
| SCHEMBL5414562 | 0.81 | HRH1 (0.75) | HRH1CCR3KCNH2 | |
| SCHEMBL6570409 | 0.80 | CCR3 (0.57) | HRH1CCR3CHRM1TP53BP1L3MBTL3 | |
| SCHEMBL6567607 | 0.80 | CCR3 (0.57) | HRH1CCR3TP53BP1L3MBTL3L3MBTL1 | |
| SCHEMBL5405625 | 0.79 | HRH1 (0.78) | HRH1CCR3CHRM1L3MBTL3L3MBTL1 | |
| SCHEMBL5411547 | 0.78 | HRH1 (0.86) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |