Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31593224 | 0.78 | CD274 (0.63) | MAPK1MEN1KMT2AAHRKDM4E | |
| SCHEMBL21229150 | 0.78 | CD274 (0.63) | MAPK1MEN1KMT2AAHRKDM4E | |
| SCHEMBL5717551 | 0.76 | MAPK1 (0.77) | MAPK1KMT2AKDM4EL3MBTL1P4HTM | |
| SCHEMBL23685216 | 0.76 | MAPK1 (0.55) | MAPK1MEN1KMT2AAHRKDM4E | |
| SCHEMBL20539977 | 0.76 | MAPK1 (0.55) | MAPK1MEN1KMT2AAHRKDM4E | |
| SCHEMBL30257716 | 0.76 | MAPK1 (0.55) | MAPK1MEN1KMT2AAHRKDM4E | |
| SCHEMBL1201691 | 0.75 | RAB9A (0.47) | MAPK1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL465733 | 0.75 | HDAC3 (0.61) | MEN1KMT2AKDM4ELMNAPOLB | |
| SCHEMBL2830289 | 0.73 | MAPK1 (0.72) | MAPK1MEN1KMT2AAHRKDM4E | |
| SCHEMBL7318242 | 0.73 | TSHR (0.58) | MAPK1MEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-02-23 | — | — | US | disclosed |
| US-8067613-B2 | Benzimidazole poly(ADP ribose)polymerase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| CN-101754967-A | Benzimidazole poly (ADP-ribose) polymerase inhibitors | ABBOTT LAB | 2010-06-23 | — | — | CN | disclosed |
| EP-2183248-A2 | BENZIMIDAZOLE POLY (ADP RIBOSE) POLYMERASE INHIBITORS | Abbott Laboratories (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | disclosed |
| WO-2009012280-A2 | BENZIMIDAZOLE POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | MAPK1 4096/4885MEN1 4272/4885KMT2A 1776/4885 |
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | MAPK1 4096/4885MEN1 4272/4885KMT2A 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.