Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568622 | 0.98 | NPC1 (0.49) | NPC1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL6659568 | 0.71 | TTR (0.39) | ALDH1A1TSHR | |
| SCHEMBL4384593 | 0.68 | KMT2A (0.51) | NPC1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL14969283 | 0.67 | KMT2A (0.53) | NPC1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL11324605 | 0.66 | NPC1 (0.54) | NPC1HPGDSMN1; SMN2KMT2APOLB | |
| SCHEMBL16965312 | 0.65 | KMT2A (0.54) | NPC1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL2646798 | 0.65 | HPGD (0.96) | NPC1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL31424351 | 0.65 | SMN1; SMN2 (0.60) | NPC1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL12713119 | 0.65 | SMN1; SMN2 (0.49) | NPC1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL11317215 | 0.65 | NPC1 (0.57) | NPC1HPGDSMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |