Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.40 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.40 |
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | CHRNA10 | Q9GZZ6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669907 | 0.98 | TP53 (0.43) | NPC1POLBRAB9ASMN1; SMN2TP53 | |
| Bromide SCHEMBL8025979 | 0.90 | TP53 (0.45) | NPC1POLBRAB9ASMN1; SMN2TP53 | |
| Sulfuric Acid SCHEMBL11632992 | 0.90 | MEN1 (0.40) | POLBTP53KCNH2MEN1KMT2A | |
| SCHEMBL5295154 | 0.83 | KCNH2 (0.49) | NPC1RAB9ASMN1; SMN2TP53KCNH2 | |
| SCHEMBL5297992 | 0.83 | KCNH2 (0.49) | NPC1RAB9ASMN1; SMN2TP53KCNH2 | |
| SCHEMBL329217 | 0.80 | NPC1 (0.46) | NPC1POLBRAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL29561039 | 0.80 | NPC1 (0.46) | NPC1POLBRAB9ASMN1; SMN2KCNH2 | |
| Bromide SCHEMBL11582464 | 0.79 | NPC1 (0.70) | NPC1POLBRAB9ASMN1; SMN2CHRNA7 | |
| Bromide SCHEMBL8983472 | 0.79 | SMN1; SMN2 (0.55) | NPC1POLBRAB9ASMN1; SMN2KCNH2 | |
| Bromide SCHEMBL11692702 | 0.79 | TP53 (0.48) | NPC1RAB9ASMN1; SMN2TP53KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925527-B1 | PHOTOGRAPHIC ELEMENT AND METHOD | POLAROID CORP (US) | 2004-04-14 | — | — | EP | disclosed |
| US-4430415-A | Heat-developable photographic material with fine droplets containing silver halide, organic silver salt oxidizing agent and color image forming substance | FUJI PHOTO FILM CO., LTD. (JP) | 1984-02-07 | — | — | US | disclosed |