Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6568586 | 0.90 | NPC1 (0.43) | TP53KCNH2NPC1POLBRAB9A | |
| SCHEMBL6669907 | 0.88 | TP53 (0.43) | TP53KCNH2NPC1POLBRAB9A | |
| Bromide SCHEMBL11692702 | 0.81 | TP53 (0.48) | TP53KCNH2NPC1RAB9ASMN1; SMN2 | |
| Sulfuric Acid SCHEMBL11632992 | 0.80 | MEN1 (0.40) | TP53KCNH2POLBCA1CA2 | |
| SCHEMBL4062501 | 0.79 | RAB9A (0.39) | TP53KCNH2NPC1POLBRAB9A | |
| Bromide SCHEMBL6229520 | 0.78 | NPC1 (0.63) | TP53KCNH2NPC1POLBRAB9A | |
| SCHEMBL18538790 | 0.77 | NPC1 (0.38) | TP53NPC1POLBRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30331115 | 0.77 | RAB9A (0.38) | TP53NPC1POLBRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL15941654 | 0.77 | NPC1 (0.41) | TP53NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL6231742 | 0.76 | NPC1 (0.60) | TP53KCNH2NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820607-B1 | PHOTOGRAPHIC SYSTEM | POLAROID CORP (US) | 2000-03-22 | — | — | EP | disclosed |
| EP-0820607-A1 | PHOTOGRAPHIC SYSTEM | POLAROID CORPORATION (US) | 1998-01-28 | — | — | EP | disclosed |
| US-5705312-A | PHOTOGRAPHIC FILM DEVELOPMENT OF SILVER HALIDE EMULSIONS TO FORM IMAGES ON SHEETS WITH RUPTURABLE CONTAINERS | POLAROID CORPORATION (US) | 1998-01-06 | — | — | US | disclosed |
| WO-1997029405-A1 | PHOTOGRAPHIC SYSTEM | POLAROID CORPORATION (US) | 1997-08-14 | — | — | WO | disclosed |
| US-4123330-A | Color diffusion transfer process using benzyl alcohol and derivatives thereof | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1978-10-31 | — | — | US | disclosed |