Glycinebetaine

Glycinebetaine

SCHEMBL6568624

C[N+](C)(C)CC(=O)[O-].Cc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.44
LMNA P02545 3/20 0.44
KDM4E B2RXH2 1/20 0.44
MAPT P10636 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CYP2C9 P11712 2/20 0.43
CYP1A2 P05177 1/20 0.43
GAA P10253 1/20 0.42
SNCA P37840 1/20 0.41
CYP2D6 P10635 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
MMP1 P03956 1/20 0.40
MMP2 P08253 1/20 0.40
MMP9 P14780 1/20 0.40
MMP8 P22894 1/20 0.40
MMP13 P45452 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetramethylammonium Ion SCHEMBL241921 0.82 GAA (0.54) ALDH1A1LMNAKDM4EMAPTHTT
SCHEMBL6909421 0.82 GAA (0.59) ALDH1A1LMNAKDM4EMAPTHTT
Hydrogen Sulfide SCHEMBL3890575 0.82 GAA (0.59) ALDH1A1LMNAKDM4EMAPTHTT
SCHEMBL11704592 0.81 CYP2C9 (0.45) ALDH1A1LMNAKDM4EMAPTHTT
Bicarbonate SCHEMBL28127133 0.81 GAA (0.52) ALDH1A1LMNAKDM4EMAPTHTT
Bicarbonate SCHEMBL28126521 0.81 GAA (0.52) ALDH1A1LMNAKDM4EMAPTHTT
SCHEMBL1705904 0.80 GAA (0.62) ALDH1A1LMNAKDM4EMAPTHTT
SCHEMBL31313 0.80 GAA (0.62) ALDH1A1LMNAKDM4EMAPTHTT
SCHEMBL34 0.80 GAA (0.62) ALDH1A1LMNAKDM4EMAPTHTT
SCHEMBL5068661 0.80 GAA (0.62) ALDH1A1LMNAKDM4EMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115772-B1 A POLYMERIC PIGMENT DISPERSANT HAVING AN ACRYLIC BACKBONE, POLYESTER SIDE CHAINS, CYCLIC IMIDE GROUPS AND QUATERNARY AMMONIUM GROUPS DU PONT (US) 2004-04-07 EP disclosed
EP-1115772-A1 A POLYMERIC PIGMENT DISPERSANT HAVING AN ACRYLIC BACKBONE, POLYESTER SIDE CHAINS, CYCLIC IMIDE GROUPS AND QUATERNARY AMMONIUM GROUPS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2001-07-18 EP disclosed
US-6037414-A USEFUL IN SOLVENT BORNE COATINGS WHERE THEY PROVIDE IMPROVED EFFICIENCY OF PIGMENT USE, LOWER PAINT VISCOSITY, REDUCED EMISSION OF VOLATILE SOLVENTS E. I. DU PONT NEMOURS AND COMPANY (US) 2000-03-14 US disclosed
WO-2000012582-A1 A POLYMERIC PIGMENT DISPERSANT HAVING AN ACRYLIC BACKBONE, POLYESTER SIDE CHAINS, CYCLIC IMIDE GROUPS AND QUATERNARY AMMONIUM GROUPS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2000-03-09 WO disclosed