Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13185669 | 0.84 | KDM4E (0.61) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL373105 | 0.83 | KDM4E (1.00) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL29631004 | 0.83 | KDM4E (1.00) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL9374034 | 0.82 | KDM4E (0.73) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL27470048 | 0.82 | KDM4E (0.63) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL27623934 | 0.82 | KDM4E (0.77) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL8567491 | 0.81 | HDAC1 (0.77) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL5903774 | 0.81 | HDAC1 (1.00) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL17204708 | 0.80 | KDM4E (0.45) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL17201603 | 0.80 | KDM4E (0.45) | KDM4EHDAC1HDAC4HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-02-23 | — | — | US | disclosed |
| US-8067613-B2 | Benzimidazole poly(ADP ribose)polymerase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| EP-2183248-A2 | BENZIMIDAZOLE POLY (ADP RIBOSE) POLYMERASE INHIBITORS | Abbott Laboratories (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | disclosed |
| WO-2009012280-A2 | BENZIMIDAZOLE POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | KDM4E 2549/4885HDAC1 65/4885HDAC4 184/4885 |
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | KDM4E 2549/4885HDAC1 65/4885HDAC4 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.