⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957 | 1.00 | — | — | |
| SCHEMBL8348118 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL11071779 | 0.97 | — | — | |
| Bicarbonate SCHEMBL7107293 | 0.87 | MAPT (0.34) | — | |
| SCHEMBL11281845 | 0.82 | — | — | |
| SCHEMBL8223380 | 0.80 | — | — | |
| SCHEMBL14463588 | 0.75 | — | — | |
| SCHEMBL11832985 | 0.71 | — | — | |
| SCHEMBL213131 | 0.67 | MAPT (0.38) | — | |
| SCHEMBL7792313 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482934-A1 | 2-METHYLTHIAZOLIDINE-2,4-DICARBOXYLIC ACID AND THE SALTS THEREOF USED FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Susilo, Rudy, Dr. (DE) | 2004-12-08 | — | — | EP | claimed |
| WO-2003072101-A1 | 2-METHYLTHIAZOLIDINE-2,4-DICARBOXYLIC ACID AND THE SALTS THEREOF USED FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | TROMMSDORFF ARZNEIMITTEL (DE) | 2003-09-04 | — | — | WO | claimed |
| US-20100286365-A1 | PEPTIDE-PEPTIDASE-INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME | AMYLIN PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2009-11-05 | — | — | US | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |