Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 15/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 15/20 | 0.60 |
| ▸ | PDK3 | Q15120 | 15/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 15/20 | 0.60 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | GLB1 | P16278 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569740 | 1.00 | PDK1 (0.60) | PDK1PDK2PDK3PDK4PPARA | |
| SCHEMBL6569674 | 0.89 | PDK1 (0.53) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6569669 | 0.89 | PDK1 (0.53) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6568197 | 0.80 | PDK1 (0.56) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6568194 | 0.80 | PDK1 (0.56) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6569560 | 0.79 | PDK1 (0.61) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6569567 | 0.79 | PDK1 (0.61) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4608656 | 0.78 | PDK1 (0.56) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4608652 | 0.78 | PDK1 (0.56) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6570973 | 0.78 | PDK1 (0.68) | PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |