Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pitolisant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 18/20 | 0.85 |
| ▸ | HRH1 | P35367 | 3/20 | 0.85 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.85 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.85 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.85 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.85 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.85 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.85 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.85 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.82 |
| ▸ | HTR2C | P28335 | 1/20 | 0.82 |
| ▸ | HTR7 | P34969 | 1/20 | 0.82 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.82 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.82 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pitolisant SCHEMBL117648 | 0.92 | HRH3 (1.00) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| Pitolisant SCHEMBL4591893 | 0.91 | HRH3 (1.00) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL6570265 | 0.87 | HRH3 (0.84) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| Pitolisant SCHEMBL4592979 | 0.85 | HRH3 (0.85) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL22561783 | 0.79 | HRH3 (0.74) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL7982901 | 0.79 | HRH3 (0.73) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL10054323 | 0.79 | HRH3 (0.74) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL2451795 | 0.78 | HRH1 (0.74) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL491655 | 0.78 | HRH3 (1.00) | HRH3HRH1SLC6A2CHRM2ADRA2C | |
| SCHEMBL491791 | 0.77 | HRH3 (0.72) | HRH3HRH1SLC6A2CHRM2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428820-A1 | Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications | BIOPROJET (FR) | 2004-06-16 | — | — | EP | disclosed |