Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pitolisant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 14/20 | 0.85 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.85 |
| ▸ | HRH1 | P35367 | 2/20 | 0.85 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.85 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.85 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.85 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.85 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.85 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.85 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.82 |
| ▸ | HTR2C | P28335 | 1/20 | 0.82 |
| ▸ | HTR7 | P34969 | 1/20 | 0.82 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.82 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pitolisant SCHEMBL117648 | 0.92 | HRH3 (1.00) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| Pitolisant SCHEMBL4591893 | 0.91 | HRH3 (1.00) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| Pitolisant SCHEMBL6570276 | 0.85 | HRH3 (0.85) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL10054323 | 0.81 | HRH3 (0.74) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL491655 | 0.81 | HRH3 (1.00) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL492156 | 0.79 | HRH3 (0.97) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL22561783 | 0.79 | HRH3 (0.74) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL7982901 | 0.79 | HRH3 (0.73) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL2451795 | 0.78 | HRH1 (0.74) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL491791 | 0.77 | HRH3 (0.72) | HRH3SLC6A2HRH1CHRM2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11945788-B2 | Process for preparing pitolisant hydrochloride and solid-state forms thereof | NURAY CHEMICALS PRIVATE LIMITED (IN) | 2024-04-02 | — | — | US | claimed |
| US-20230219914-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | Nuray Chemicals Private Limiited (IN) | 2023-07-13 | — | — | US | claimed |
| US-20220402886-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | Nuray Chemicals Private Lmiited (IN) | 2022-12-22 | — | — | US | claimed |
| US-20260034114-A1 | ENTERIC COATED PITOLISANT FORMULATIONS AND METHODS OF USE | BIOPROJET PHARMA (FR) | 2026-02-05 | — | — | US | disclosed |
| US-20250186353-A1 | ENTERIC COATED PITOLISANT FORMULATIONS AND METHODS OF USE | HARMONY BIOSCIENCES, LLC | 2025-06-12 | — | — | US | disclosed |
| WO-2025082974-A1 | NEW FORMULATIONS OF PITOLISANT AND METHODS OF USE | BIOPROJET PHARMA (FR) | 2025-04-24 | — | — | WO | disclosed |
| WO-2025082972-A1 | ENTERIC COATED PITOLISANT FORMULATIONS AND METHODS OF USE | BIOPROJET PHARMA (FR) | 2025-04-24 | — | — | WO | disclosed |
| US-20250120959-A1 | NEW FORMULATIONS OF PITOLISANT AND METHODS OF USE | BIOPROJET PHARMA (FR) | 2025-04-17 | — | — | US | disclosed |
| US-11945788-B2 | Process for preparing pitolisant hydrochloride and solid-state forms thereof | NURAY CHEMICALS PRIVATE LIMITED (IN) | 2024-04-02 | — | — | US | disclosed |
| US-20230219914-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | Nuray Chemicals Private Limiited (IN) | 2023-07-13 | — | — | US | disclosed |
| US-11623920-B2 | Process for preparing pitolisant hydrochloride and solid-state forms thereof | NURAY CHEMICALS PRIVATE LIMITED (IN) | 2023-04-11 | — | — | US | disclosed |
| US-8354430-B2 | Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl) propoxy]propyl]-piperidine | BIOPROJET (FR) | 2013-01-15 | — | — | US | disclosed |
| US-20120289546-A1 | MONOHYDROCHLORIDE SALT OF 1-[3-[3-(4-CHLOROPHENYL) PROPOXY]PROPYL]-PIPERIDINE | RAGA MANUEL (ES) | 2012-11-15 | — | — | US | disclosed |
| US-8207197-B2 | Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl) propoxy] propyl] -piperidine | BIOPROJET (FR) | 2012-06-26 | — | — | US | disclosed |
| US-20080221162-A1 | Monohydrochloride Salt of 1-[3-[3-(4-Chlorophenyl) Propoxy] Propyl] -Piperidine | BIOPROJET (FR) | 2008-09-11 | — | — | US | disclosed |
| EP-1846384-B1 | MONOHYDROCHLORIDE SALT OF 1-[3-[3-(4-CHLOROPHENYL)PROPOXY]PROPYL]-PIPERIDINE | BIOPROJET SOC CIV (FR) | 2008-07-23 | — | — | EP | disclosed |
| EP-1690858-B1 | Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine | BIOPROJET SOC CIV (FR) | 2008-04-09 | — | — | EP | disclosed |
| EP-1846384-A1 | MONOHYDROCHLORIDE SALT OF 1-[3-[3-(4-CHLOROPHENYL)PROPOXY]PROPYL]-PIPERIDINE | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006084833-A1 | MONOHYDROCHLORIDE SALT OF 1- [3- [3- (4-CHLOROPHENYL) PROPOXY] PROPYL] -PIPERIDINE | BIOPROJET (FR) | 2006-08-17 | — | — | WO | disclosed |
| EP-1690858-A1 | Monohydrochloride salt of 1-¬3-¬3-(4-chlorophenyl)propoxy|propyl|-piperidine | FERRER INTERNACIONAL, S.A. (ES) | 2006-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402886-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | PITHD1, MLN, TPP1 | HRH3 1919/4885SLC6A2 295/4885HRH1 1611/4885 |
| US-20260034114-A1 | ENTERIC COATED PITOLISANT FORMULATIONS AND METHODS OF USE | ATG13, WIZ, SI | HRH3 292/4885SLC6A2 142/4885HRH1 456/4885 |
| US-20250120959-A1 | NEW FORMULATIONS OF PITOLISANT AND METHODS OF USE | MLN, SI, PGA5 | HRH3 1066/4885SLC6A2 377/4885HRH1 1177/4885 |
| US-11945788-B2 | Process for preparing pitolisant hydrochloride and solid-state forms thereof | PITHD1, MLN, TPP1 | HRH3 1919/4885SLC6A2 295/4885HRH1 1611/4885 |
| US-20080221162-A1 | Monohydrochloride Salt of 1-[3-[3-(4-Chlorophenyl) Propoxy] Propyl] -Piperidine | PHLPP1, AQP4, P4HA1 | HRH3 49/4885SLC6A2 2876/4885HRH1 296/4885 |
| US-20230219914-A1 | PROCESS FOR PREPARING PITOLISANT HYDROCHLORIDE AND SOLID-STATE FORMS THEREOF | PITHD1, MLN, TPP1 | HRH3 1919/4885SLC6A2 295/4885HRH1 1611/4885 |
| US-20120289546-A1 | MONOHYDROCHLORIDE SALT OF 1-[3-[3-(4-CHLOROPHENYL) PROPOXY]PROPYL]-PIPERIDINE | P4HA1, PAH, HRH3 | HRH3 3/4885SLC6A2 1090/4885HRH1 12/4885 |
| US-11623920-B2 | Process for preparing pitolisant hydrochloride and solid-state forms thereof | PITHD1, MLN, TPP1 | HRH3 1919/4885SLC6A2 295/4885HRH1 1611/4885 |
| US-20250186353-A1 | ENTERIC COATED PITOLISANT FORMULATIONS AND METHODS OF USE | MLN, SI, SLC10A2 | HRH3 1757/4885SLC6A2 412/4885HRH1 1700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.