⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24459 | 0.35 | — | — | |
| SCHEMBL13523738 | 0.35 | — | — | |
| SCHEMBL4584754 | 0.35 | — | — | |
| SCHEMBL15342 | 0.31 | — | — | |
| SCHEMBL31122749 | 0.31 | ALDH1A1 (0.33) | — | |
| SCHEMBL21951725 | 0.29 | — | — | |
| SCHEMBL1517356 | 0.29 | — | — | |
| Methane SCHEMBL23044967 | 0.25 | — | — | |
| SCHEMBL8425118 | 0.25 | — | — | |
| SCHEMBL6264766 | 0.25 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112375027-A | Indolesulfonamide derivative and medical application thereof | 中国药科大学 | 2021-02-19 | — | — | CN | claimed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | claimed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | claimed |
| US-9809599-B2 | Aryl-quinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-11-07 | — | — | US | claimed |
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | claimed |
| EP-2888245-B1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | claimed |
| US-20160060270-A1 | New Aryl-Quinoline Derivatives | HOFFMANN-LA ROCHE INC. | 2016-03-03 | — | — | US | claimed |
| US-20150368256-A1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-12-24 | — | — | US | claimed |
| EP-2888245-A1 | NEW BICYCLICPYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | claimed |
| EP-2773619-A1 | NEW ARYL-QUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-10 | — | — | EP | claimed |
| US-4536507-A | ANTIASTHMA AGENTS | MERCK & CO., INC. (US) | 1985-08-20 | — | — | US | claimed |
| EP-0138533-A2 | 6H-dibenz(b,f)thiepin compounds | MERCK FROSST CANADA INC. (CA) | 1985-04-24 | — | — | EP | claimed |
| EP-0052912-B1 | 7-FLUORO-DIBENZO(B,F)THIEPIN DERIVATIVES, THEIR PREPARATION AND RESOLUTION, AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1985-02-06 | — | — | EP | claimed |
| EP-0092830-A2 | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and their application | CIBA-GEIGY AG (CH) | 1983-11-02 | — | — | EP | claimed |
| EP-0069810-A1 | Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions | MERCK & CO. INC. (US) | 1983-01-19 | — | — | EP | claimed |
| EP-0000978-B1 | 7-AND 8-SUBSTITUTED -10,11-DIHYDRO-11-OXODIBENZO (B,F) THIEPIN DERIVATIVES, THEIR PRODUCTION AND THEIR PARMACEUTICAL COMPOSITIONS | MERCK & CO. INC. (US) | 1982-09-15 | — | — | EP | claimed |
| EP-0052912-A1 | 7-Fluoro-dibenzo(b,f)thiepin derivatives, their preparation and resolution, and compositions containing them | MERCK & CO. INC. (US) | 1982-06-02 | — | — | EP | claimed |
| EP-0011067-B1 | PROSTAGLANDIN ANTAGONISTS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | claimed |
| EP-0011067-A1 | Prostaglandin antagonists, their production and their pharmaceutical compositions | MERCK & CO. INC. (US) | 1980-05-28 | — | — | EP | claimed |
| EP-0000978-A1 | 7-and 8-substituted -10,11-dihydro-11-oxodibenzo (b,f) thiepin derivatives, their production and their parmaceutical compositions | MERCK & CO. INC. (US) | 1979-03-07 | — | — | EP | claimed |