Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10584005 | 0.81 | UGT2B7 (0.46) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7502486 | 0.81 | UGT2B7 (0.46) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11051116 | 0.79 | UGT2B7 (0.55) | UGT2B7CYP2D6MEN1CYP1A2TSHR | |
| SCHEMBL14533204 | 0.79 | SLC6A2 (0.52) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10580403 | 0.79 | CYP2D6 (0.43) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10579923 | 0.79 | CYP2D6 (0.43) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10583568 | 0.79 | CYP2D6 (0.43) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10583661 | 0.79 | CYP2D6 (0.43) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10583789 | 0.79 | CYP2D6 (0.43) | UGT2B7CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7764729 | 0.78 | AOC3 (0.42) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404325-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002096420-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2002-12-05 | — | — | WO | disclosed |