Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.56 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.56 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.54 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | PTPRA | P18433 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571465 | 0.91 | PTPN1 (0.65) | PTPN1PTPN22PTPRA | |
| SCHEMBL6573532 | 0.90 | PTPN1 (0.60) | PTPN1PTPN22PSMB8PSMB9PSMB5 | |
| SCHEMBL6572704 | 0.88 | PTPN1 (0.58) | PTPN1PTPN22PSMB8PSMB9PSMB5 | |
| SCHEMBL6572579 | 0.87 | PTPN1 (0.64) | PTPN1PTPN22PTPRA | |
| SCHEMBL6572795 | 0.87 | PTPN1 (0.61) | PTPN1PTPN22PTPRA | |
| SCHEMBL6572629 | 0.87 | PTPN1 (0.67) | PTPN1PTPN22PTPRA | |
| SCHEMBL6572625 | 0.87 | PTPN1 (0.67) | PTPN1PTPN22PTPRA | |
| SCHEMBL6573618 | 0.86 | PTPN1 (0.59) | PTPN1PTPN22PTPRA | |
| SCHEMBL6573353 | 0.86 | PTPN1 (0.52) | PTPN1SIRT2SIRT1SIRT3 | |
| SCHEMBL6574701 | 0.86 | PTPN1 (0.60) | PTPN1PTPN22PTPRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | claimed |
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | claimed |
| EP-1019364-B1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2004-06-09 | — | — | EP | disclosed |
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | disclosed |